Stéphane Roy
- Professeur titulaire
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Faculté de médecine dentaire - Département de stomatologie
Roger-Gaudry office D555
- Professeur accrédité
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Faculté de médecine - Département de biochimie et médecine moléculaire
Roger-Gaudry
Télécopieur : 514 343-2233
Web : Page professionnelle (faculté,département,école)
Web : Site web de l’unité de recherche
Web : Autre site web
Affiliations
- Directeur – Laboratoire de recherche sur la régénération tissulaire chez les vertébrés
- Membre – CIUSSS NIM — Centre de recherche du CIUSSS Nord-de-l’île-de-Montréal
- Membre – RSBO — Réseau de recherche en santé buccodentaire et osseuse
Expertises
Functional analysis of the TGF-beta signalling pathway and the p53 tumour suppressor gene during limb regeneration and cancer resistance in axolotls.
Responsabilities and outreach Expand all Collapse all
Student supervision Expand all Collapse all
Cycle : Master's
Grade : M. Sc.
Research projects Expand all Collapse all
The Axolotl a model for vertebrate limb regeneration. Projet de recherche au Canada / 2023 - 2029
Réseau de recherche en santé buccodentaire et osseuse-RSBO - Comparing gene expression profiles between cancer resistant axolotls and human oral cancers to help identify potential therapeutic targets. Projet de recherche au Canada / 2022 - 2025
Role of cellular senescence in vertebrate development and metamorphosis Projet de recherche au Canada / 2017 - 2024
Supplément COVID-19 CRSNG_Role of cellular senescence in vertebrate development and metamorphosis Projet de recherche au Canada / 2020 - 2021
(RSBO) - Explorations des effets d'AINS sur la régulation de l'ACE2 et du récepteur MAS, deux facteurs qui risquent d'aggraver les effets du Covid-19 Projet de recherche au Canada / 2020 - 2021
Préparation et évaluation de matrice extra-cellulaire de peau d'axolotl pour l'induction de la régénération chez les mammifères Projet de recherche au Canada / 2015 - 2019
FUNCTIONAL ANALYSIS OF THE TGF-BETA/SMAD SIGNALLING PATHWAY IN REGENERATION Projet de recherche au Canada / 2011 - 2017
Rapid Selection of Monoclonal Antibodies Against Axolotl Epitopes Projet de recherche au Canada / 2015 - 2016
FUNCTIONAL ANALYSIS OF THE TGF-BETA/SMAD SIGNALLING PATHWAY IN REGENERATION Projet de recherche au Canada / 2010 - 2015
RESEAU DE RECHERCHE EN SANTE BUCCODENTAIRE ET OSSEUSE (RSBO) - THE AXOLOTL (URODELE) AS A MODEL TO STUDY SALIVARY GLAND REGENERATION FOLLOWING HEAD AND NECK IRRADIATION AND SURGICAL RESECTION Projet de recherche au Canada / 2011 - 2013
ROLE OF TGF-BETA/SMAD SIGNALLING DURING TISSUE REGENERATION IN AXOLOTLS Projet de recherche au Canada / 2008 - 2008
Publications Expand all Collapse all
dernière 5 années
27. Zillian C, Dodelet-Devillers A, Roy S and Vachon P.
Evaluation of the anesthetic effects of MS222 in the adult Mexican axolotl (A. mexicanum).
Veterinary Medicine: Research and Reports 2016:7 p1-7.
28. Denis JF, Sader F, Gatien S, Villiard É, Philip A and Roy S.
Activation of Samd2 but not Smad3 is required for mediating TGF-beta signaling during limb regeneration in axolotls.
Development 2016 Oct 1;143(19):3481-3490
29. Charbonneau AM, Roy S, Tran SD.
Oral-facial tissue reconstruction in the regenerative axolotl.
J. Exp. Zool. (Mol. Dev. Evol.) 2016; 326B:489–502.(Cover article)
30. Villiard É, Denis JF, Hashemi FS, Igelmann S, Ferbeyre G and Roy S.
Senescence gives insights into the morphogenetic evolution of anamniotes.
Biology Open 2017 June 15;6(6): 891-896. Open access.
31. Sader F, Denis JF and Roy S.
Tissue regeneration in dentistry: can salamanders provide insight?
Oral Diseases 2018 May; 24(4):509-517
32. Alzahrani A, Chi Y, Finnson KW, Blati M, Lussier B, Kapoor M, Roy S, Philip A.
Endoglin haploinsufficiency is associated with differential regulation of extracellular matrix production during skin fibrosis and cartilage repair in mice.
J Cell Commun Signal. 2018 Mar; 12(1):379-388.
33. Sader F, Denis JF, Laref H and Roy S.
Epithelial to mesenchymal transition is mediated by both TGF-b canonical and non-canonical signaling during axolotl limb regeneration.
Scientific Reports 2019 Feb 4; 9(1):1144. Open access.
34. Vincent É, Villiard É, Sader F, Dhakal S, Kwok BH and Roy S.
BMP signaling is essential for sustaining proximo-distal progression in regenerating axolotl limbs.
Development 2020 Jul 31; 147(14): dev170829.
35. Sader F and Roy S.
Dev Dyn 2022 251:6 p.973-987 doi: 10.1002/dvdy.379.
36. Charbonneau AM, Åström P, Salo T, Roy S*, Tran SD*.
Cells Tissues Organs 2021 210:4 p260-274 doi: 10.1159/000518036
Communications Expand all Collapse all
Dernière 5 années:
54. Sader F, Laref H and Roy S.
Studying EMT processes during Axolotl limb regeneration.
EMBO conference: The molecular and cellular basis of regeneration and tissue repair, 17-21 September 2016, Paestum (Salerno), Italy.
55. Denis JF and Roy S.
Differential activation of Smad is at the heart of the regeneration process.
EMBO conference: The molecular and cellular basis of regeneration and tissue repair, 17-21 September 2016, Paestum (Salerno), Italy.
56. Sader F and Roy S.
Understanding the signaling of EMT processes during axolotl limb regeneration.
9th Canadian Developmental Biology Conference (Mont-Tremblant Que) March 19th-22nd 2018.
57. Vincent E, Villiard E, Sader F, Denis JF and Roy S.
Inhibition of BMP signaling demonstrates that limb regeneration in axolotl progresses in a proximo-distal fashion.
9th Canadian Developmental Biology Conference (Mont-Tremblant Que) March 19th-22nd 2018.
58. Mathavarajah S, Salsman J, Braasch I, Roy S and Dellaire G.
PML and PML-like exon 9 (Plex9) proteins regulate LINE retrotransposition in anamniotes. Canadian Society of Molecular Biosciences 64th annual conference. June 14-17 2021. Virtual conference. Poster presentation.
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